Differential expression pattern-based prioritization of candidate genes through integrating disease-specific expression data
نویسندگان
چکیده
منابع مشابه
GeneTIER: prioritization of candidate disease genes using tissue-specific gene expression profiles
MOTIVATION In attempts to determine the genetic causes of human disease, researchers are often faced with a large number of candidate genes. Linkage studies can point to a genomic region containing hundreds of genes, while the high-throughput sequencing approach will often identify a great number of non-synonymous genetic variants. Since systematic experimental verification of each such candida...
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OBJECTIVES To develop and apply a model for prioritization of candidate glaucoma genes. METHODS This Affymetrix GeneChip (Affymetrix, Santa Clara, Calif) study of gene expression in primary culture human trabecular meshwork cells uses a positional differential expression profile model for prioritization of candidate genes within the GLC1C genetic inclusion interval. RESULTS Sixteen genes we...
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Invasive aspergillosis is a severe opportunistic infection with high mortality in immunocompromised patients. Recently, the roles of microRNAs have been taken into consideration in the immune system and inflammatory responses. Using bioinformatics approaches, we aimed to study the microRNAs related to invasive aspergillosis to understand the molecular pathways involved in the disease pathogenes...
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Microarray data analysis has been shown to provide an effective tool for studying cancer and genetic diseases. Although classical machine learning techniques have successfully been applied to find informative genes and to predict class labels for new samples, common restrictions of microarray analysis such as small sample sizes, a large attribute space and high noise levels still limit its scie...
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Identifying disease genes is very important not only for better understanding of gene function and biological process but also for human medical improvement. Many previous methods are based on modular nature of human genetic disease and the similarity between known disease genes and candidate genes. In this paper, we propose the method of Modularized Random Walk with Restart (MRWR) based on the...
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ژورنال
عنوان ژورنال: Genomics
سال: 2011
ISSN: 0888-7543
DOI: 10.1016/j.ygeno.2011.04.001